The Mayflower stayed with the Pilgrims in America the first winter, and departed home for England in April, arriving back home in May 1621.  Master Christopher Jones, the ship's captain, died the next year, in March 1622.  Christopher Jones owned a fourth of the ship, and when he died the ownership of his share passed to his widow, Josian. 

Josian, with the other three owners, stopped using the ship, and by May 1624 it had fallen into ruins.  It was appraised at that time to a value of just over £128, and because of its very poor condition it was almost certainly broken up and sold off as scrap.

Shortly before the 300th anniversary of the Mayflower's voyage (1920), a historian by the name of J. Rendell Harris published a book, The Finding of the Mayflower, in which he claimed to have rediscovered the Mayflower, as a barn in Jordans, England.  However, his evidence was extremely speculative, much of it based on oral tradition that he himself may have initiated and encouraged; and the possible family connections between the barn owners and the Mayflower's owners has not stood the test of subsequent research.  The barn likely is the remains of a 17th century ship, but there is no evidence it is actually the Mayflower.